Colorectal Cancer on the Decline — Why Screening Can’t Explain It All
Cet article passe en revue les facteurs susceptibles de rendre compte de la baisse de la mortalité par cancer colorectal aux Etats-Unis, et notamment du rôle joué par les programmes de dépistage
Unlike screening for breast or prostate cancer, screening for colorectal cancer promises not only to find cancer early, but also to prevent it from occurring. In the 1960s, Gilbertsen first suggested that polypectomy could turn colorectal cancer into a preventable disease. Two decades later, Vogelstein envisioned the polyp-to-cancer progression as a stepwise process and detailed the genetic alterations that occur at each step. Colorectal cancer became widely viewed as having a long latency period — providing ample time for both early detection and prevention. Conditions were thus considered ideal for screening to reduce related mortality...
New England Journal of Medicine , article en libre accès, 2015