Proton Beam Radiation Therapy : The Future May Prove Brighter for Pediatric Patients With Brain Tumors
Menée sur 150 patients pédiatriques atteints d'une tumeur au cerveau traité entre 2002 et 2012, cette étude évalue, par rapport à une radiothérapie par faisceaux de photons, l'effet d'une protonthérapie sur l'évolution des capacités intellectuelles des patients
Multiple meta-analyses have demonstrated significant deficits in overall intellectual abilities, academic functioning, and specific cognitive skills, including attention, processing speed, and executive function, among pediatric brain tumor survivors treated with photon radiotherapy (XRT). The physical characteristics of heavy proton particles used in proton beam radiation therapy (PBRT), which permits delivery of maximal dose at the desired depth of tissue penetration while minimizing the exit dose of radiation to healthy surrounding tissue, have been well described.5 What has been missing from the literature is the extent to which proton radiation therapy (RT) differs from XRT in terms of cognitive, academic, visual, auditory, endocrine, vascular, and skin late effects.
Journal of Clinical Oncology , éditorial en libre accès, 2016