Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers
A partir de données issues du projet "The Cancer Genome Atlas" portant sur 5 037 tumeurs (13 types de cancer), cette étude présente une méthode pour identifier de façon systématique des longs ARNs non codants impliqués dans la cancérogenèse
The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments.
Cancer Cell , résumé, 2014