Immunology and Immunotherapy of Head and Neck Cancer
Ce dossier présente un ensemble d'articles sur la prise en charge de certains cancers de la tête et du cou (larynx, pharynx, cavité buccale, ...) et aborde l'épidémiologie des carcinomes épidermoïdes liés au papillomavirus humain ainsi que les anomalies et interactions moléculaires pouvant favoriser le développement de tumeurs rhinopharyngées
The immune system plays a key role in the development, establishment, and progression of head and neck squamous cell carcinoma (HNSCC). A greater understanding of the dysregulation and evasion of the immune system in the evolution and progression of HNSCC provides the basis for improved therapies and outcomes for patients. HNSCC cells evade the host immune system through manipulation of their own immunogenicity, production of immunosuppressive mediators, and promotion of immunomodulatory cell types. Through the tumor's influence on the microenvironment, the immune system can be exploited to promote metastasis, angiogenesis, and growth. This article provides a brief overview of key components of the immune infiltrating cells in the tumor microenvironment, reviewing immunological principles related to head and neck cancer, including the concept of cancer immunosurveillance and immune escape. Current immunotherapeutic strategies and emerging results from ongoing clinical trials are presented.
Journal of Clinical Oncology , résumé, 2015