Circulating 25-Hydroxyvitamin D3 and survival after diagnosis with kidney cancer
A partir des données d'une étude cas-témoins multicentrique menée en Europe, cette étude évalue l'association entre la concentration sérique en vitamine D3 au moment du diagnostic et la survie des patients atteints d'un carcinome à cellules rénales
Background: We evaluated whether concentrations of vitamin D at diagnosis of renal cell carcinoma (RCC) is associated with prognosis.
Methods: We conducted a case-cohort study of 630 RCC cases, including 203 deaths) from a multi-centre case-control study in Eastern Europe. Vitamin D was assessed as 25-hydroxyvitamin D3 [25(OH)D3], and we used weighted Cox models to estimate hazard ratios (HR) and 95% confidence intervals (CI) by categories of season-adjusted 25(OH)D3.
Results: Higher concentrations of 25(OH)D3 were associated with lower risk of death after adjusting for stage, age, sex, and country (HR highest versus lowest category 0.57, 95% CI [0.34, 0.97]). The inverse associations of 25(OH)D3 with death were most notable among those who died from non-RCC causes and those diagnosed with early stage disease.
Conclusions: 25(OH)D3 concentration at diagnosis of RCC was inversely associated with all-cause mortality rates, but not specifically with RCC outcome.
Cancer Epidemiology Biomarkers & Prevention , résumé, 2015