Urinary Prostaglandin E2 Metabolite and Breast Cancer Risk
Couplée aux données de la cohorte chinoise "Shanghai Women's Health Study" incluant 74 941 femmes et portant sur 504 cas et 1 082 témoins, cette étude évalue l'association entre le niveau de métabolites urinaires de la prostaglandine E2 et le risque de cancer du sein
Background : Levels of the cyclooxygenase 2 (COX-2) enzyme are elevated in breast cancer tissue, and most COX-2 effects are believed to be mediated through overproduction of prostaglandin-E2 (PGE2). We evaluated associations between the primary urinary metabolite of PGE2 (PGE-M) and breast cancer risk.
Methods : A nested case-control study of 504 cases and 1,082 controls was conducted using data from the Shanghai Women's Health Study, a large population-based prospective cohort study of 74,941 Chinese women. Urinary PGE-M was measured using a liquid chromatography/tandem mass spectrometric method. Logistic regression estimated odds ratios (OR) and 95% confidence intervals (95%CI), with adjustment for potential confounders.
Results : Overall, no association between urinary PGE-M and breast cancer was detected. However, a suggestive positive association was found among postmenopausal women. In particular, a clear dose-response relationship between urinary PGE-M and breast cancer was observed among postmenopausal women with a BMI<25 kg/m2 (P for linear trend = 0.005). Among these women, risk of breast cancer increased from 1.00 (reference) to 1.06 (95% CI: 0.56-1.99), 1.50 (95% CI: 0.79-2.83), and 2.32 (95% CI: 1.24-4.41) for the lowest to highest quartiles of PGE-M, and such associations were stronger among those who were diagnosed with cancer within the first 4 years of sample collection. No apparent association was observed among overweight postmenopausal women (BMI≥25 kg/m2).
Conclusion : High urinary PGE-M level was associated with elevated risk of breast cancer among normal weight, postmenopausal women. Impact. Urinary PGE-M level may be useful for breast cancer risk assessment among normal weight, postmenopausal women.
Cancer Epidemiology Biomarkers & Prevention , résumé, 2014