TERT and BRAF in Thyroid Cancer: Teaming Up for Trouble
Menée à partir de données portant sur 507 patients atteints d'un cancer papillaire de la thyroïde (âge : 32 à 60 ans ; durée médiane de suivi : 24 mois), cette étude met en évidence une association entre la présence simultanée de deux gènes mutés (mutation C228T du gène TERT et mutation V600E du gène BRAF) et la forme la plus agressive de la maladie
The Roman philosopher Seneca refers to the idea that every so-called sin or outcome is the result of a series of complex interconnected factors. This rings true of much of biology, particularly cancer biology.
Substantial developments have occurred in the last 5 to 10 years to help us better understand the molecular complexity of thyroid cancer. Among all thyroid cancers, the most common type is papillary thyroid carcinoma (PTC), which comprises approximately 75% of all thyroid cancers. Somatic BRAF mutation was first discovered in thyroid cancer in 2003...
Journal of Clinical Oncology , éditorial, 2014