Routine Echocardiography Screening for Asymptomatic Left Ventricular Dysfunction in Childhood Cancer Survivors: A Model-Based Estimation of the Clinical and Economic Effects
A partir des données de la cohorte "Childhood Cancer Survivor Study", ces études analysent le rapport coût-efficacité d'un suivi cardiaque en routine par échocardiographie pour détecter précocement des dysfonctionnements asymptomatiques du ventricule gauche et d'une insuffisance cardiaque subséquente chez des survivants d'un cancer de l'enfance
Background: Childhood cancer survivors treated with cardiotoxic therapies are recommended to have routine cardiac assessment every 1 to 5 years, but the long-term benefits are uncertain.
Objective: To estimate the cost-effectiveness of routine cardiac assessment to detect asymptomatic left ventricular dysfunction and of angiotensin-converting enzyme inhibitor and β-blocker treatment to reduce congestive heart failure (CHF) incidence in childhood cancer survivors.
Design: Simulation model.Data Sources: Literature, including data from the Childhood Cancer Survivor Study.
Target Population: Childhood cancer survivors.Time Horizon: Lifetime.Perspective: Societal.Intervention: Interval-based echocardiography assessment every 1, 2, 5, or 10 years, with subsequent angiotensin-converting enzyme inhibitor or β-blocker treatment for patients with positive test results.Outcome Measures: Lifetime risk for systolic CHF, lifetime costs, quality-adjusted life expectancy, and incremental cost-effectiveness ratios (ICERs).
Results of Base-Case Analysis: The lifetime risk for systolic CHF among 5-year childhood cancer survivors aged 15 years was 18.8% without routine cardiac assessment (average age at onset, 58.8 years). Routine echocardiography reduced lifetime risk for CHF by 2.3% (with assessment every 10 years) to 8.7% (annual assessment). The ICER for assessment every 10 years was $111 600 per quality-adjusted life-year (QALY) compared with no assessment. Assessment every 5 years had an ICER of $117 900 per QALY, and ICERs for more frequent assessment exceeded $165 000 per QALY.
Results of Sensitivity Analysis: Results were sensitive to treatment effectiveness, absolute excess risk for CHF, and asymptomatic left ventricular dysfunction asymptomatic period. The probability that assessment every 10 or 5 years was preferred at a $100 000-per-QALY threshold was 0.33 for the overall cohort.Limitation: Treatment effectiveness was based on adult data.
Conclusion: Current recommendations for cardiac assessment may reduce CHF incidence, but less frequent assessment may be preferable.Primary Funding Source: National Cancer Institute.
Annals of Internal Medicine , résumé, 2013