Prognostic nomogram for nonresectable pancreatic cancer treated with gemcitabine-based chemotherapy
Menée sur une cohorte de 531 patients atteints d'un cancer non résécable du pancréas traité par chimiothérapie à base de gemcitabine, cette étude japonaise évalue la performance d'un nomogramme incorporant six critères (âge, sexe, taille tumorale, état de santé, présence de métastases au niveau des ganglions régionaux et de métastases distantes) pour prédire la survie des patients
Background : A nomogram is progressively being used as a useful predictive tool for cancer prognosis. A nomogram to predict survival in nonresectable pancreatic cancer treated with chemotherapy has not been reported.
Methods : Using prospectively collected data on patients with nonresectable pancreatic cancer receiving gemcitabine-based chemotherapy at five Japanese hospitals, we derived a predictive nomogram and internally validated it using a concordance index and calibration plots.
Results : In total, 531 patients were included between June 2001 and February 2013. The American Joint Committee on Cancer (AJCC) TNM stages were III and IV in 204 and 327 patients, respectively. The median survival time of the total cohort was 11.3 months. A nomogram was generated to predict survival probabilities at 6, 12, and 18 months and median survival time, based on the following six variables: age; sex; performance status; tumour size; regional lymph node metastasis; and distant metastasis. The concordance index of the present nomogram was higher than that of the AJCC TNM staging system at 12 months (0.686 vs 0.612). The calibration plots demonstrated good fitness of the nomogram for survival prediction.
Conclusions : The present nomogram can provide valuable information for tailored decision-making early after the diagnosis of nonresectable pancreatic cancer.
British Journal of Cancer , résumé, 2013