Stereotactic radiosurgery for more than four brain metastases
Menée au japon sur 1 194 patients présentant 1 à 10 métastases cérébrales (volume tumoral : < 10 ml ; diamètre tumoral : < 3 cm ; volume total cumulé ≤15 ml), cette étude prospective multicentrique évalue, du point de vue de la survie globale et en fonction du nombre de métastases, l'efficacité en traitement initial d'une radiochirurgie stéréotaxique sans radiothérapie du cerveau entier
Whole-brain radiotherapy (WBRT) had been the standard treatment for patients with newly diagnosed brain metastases, irrespective of histology and number of tumours. In view of the concerns about neurocognitive and memory deficits after WBRT, attempts have been made to treat patients with one to four brain metastases using stereotactic radiosurgery alone. 1—4 Results of three randomised trials 1—3 comparing stereotactic radiosurgery and stereotactic radiosurgery plus WBRT for patients with one to thr ...
The Lancet Oncology , commentaire, 2013