Bone mineral density and the risk of breast cancer: A case-control study of Korean women
Menée en Corée auprès de 253 cas et de 506 témoins, cette étude évalue l'association entre la densité minérale osseuse et le risque de cancer du sein
Purpose : Bone mineral density (BMD) may be useful as a surrogate marker reflecting lifetime exposure to estrogen in a woman. Our study aimed to investigate an association between bone mineral density (BMD) and breast cancer risk.
Methods : A case-control study was conducted for 253 breast cancer cases and 506 age and menopausal status-matched controls at the same institution. Cases were ascertained through medical record review of the women with abnormal mammographic findings. BMD were measured at lumbar spine and femoral neck using a dual-energy X-ray absorptiometry. The association was estimated by conditional logistic regression analysis with an adjustment for covariates.
Results : Although there was no difference in the association between pre- and postmenopausal disease, the association between BMD and breast cancer was evident for postmenopausal breast cancer. One standard deviation in age and menopausal status adjusted BMD at lumbar spine and femur neck was associated with 1.35 fold (standard error=0.19, p=0.04) and 1.34 fold (standard error=0.20, p=0.05) increased likelihood of breast cancer risk, respectively, for postmenopausal women.
Conclusion : After adjusting for covariates, higher BMD at lumbar spine and femur neck are associated with increased likelihood of breast cancer risk for postmenopausal women. These findings suggest that BMD could be included in breast cancer prediction model of postmenopausal Korean women.
Annals of Epidemiology , résumé, 2012