RIsk and risk reduction of major coronary events associated with contemporary breast radiotherapy
Menée sur 48 patientes atteintes d'un cancer du sein de stade 0 à IIA traité par radiothérapie à partir de 2005 (âge : 31 à 87 ans) et à l'aide de données d'une étude récente portant sur des patientes traitées par radiothérapie entre 1958 et 2001, cette étude estime le risque d'événements coronariens majeurs induits par la radiothérapie mammaire actuelle
Long-term breast cancer survival rates have improved markedly over recent decades, so minimization of long-term treatment-related complications is increasingly important. Several reports have suggested links between breast cancer radiotherapy and long-term cardiovascular mortality.1 A recent analysis by Darby et al2 of patients treated with breast radiotherapy between 1958 and 2001 revealed a statistically significant linear dependence of the risk of major coronary events on mean cardiac dose. We use these historical data to estimate risks of major coronary events induced by modern breast radiotherapy. Our motivation is to quantify contemporary risks and also to guide efforts to minimize radiotherapy-induced cardiovascular risks.
JAMA Internal Medicine , résumé, 2012