Comparison Between Gleason Score and Apparent Diffusion Coefficient Obtained from Diffusion-Weighted Imaging of Prostate Cancer Patients
Menée sur 40 patients atteints d'un cancer de la prostate, cette étude analyse la corrélation entre le score de Gleason et le coefficient de diffusion apparent calculé à partir des résultats d'une IRM pondérée en diffusion
Objectives : To correlate the apparent diffusion coefficient (ADC) of prostate cancer patients with pathological Gleason scores (GS).
Methods : 40 patients with GS 2 + 3, 3 + 3, 3 + 4, or 4 + 4 were selected. The magnetic resonance imaging (MRI) study was performed adding axial diffusion-weighted imaging (DWI) sequences to the standard MRI protocol. ADC values obtained were correlated with the GS data.
Results : Statistically significant differences of ADC (p < .05) were found among GS groups with a trend of decreasing ADC values with increasing GS.
Conclusions : The ADC values may help clinicians to delineate prostate carcinoma, recognizing its high- or low-grade compartments.
Cancer Investigation , résumé, 2012