Prospective Evaluation of Serum Sarcosine and Risk of Prostate Cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Menée sur 1 122 cas de cancer de la prostate et 1 112 témoins inclus dans la cohorte américaine "Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial", cette étude évalue l'association entre les niveaux sériques de sarcosine et le risque de cancer de la prostate
Metabolomic profiling has identified, sarcosine, a derivative of the amino acid glycine, as an important metabolite involved in the etiology or natural history of prostate cancer. We examined the association between serum sarcosine levels and risk of prostate cancer in 1,122 cases (813 non-aggressive and 309 aggressive) and 1,112 controls in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Sarcosine was quantified using high-throughput liquid chromatography-mass spectrometry. A significantly increased risk of prostate cancer was observed with increasing levels of sarcosine (Odds Ratio (OR) for the highest quartile of exposure (Q4) versus the lowest quartile (Q1) = 1.30, 95% CI: 1.02, 1.65; P-trend 0.03). When stratified by disease aggressiveness, we observed a stronger association for nonaggressive cases (OR for Q4 vs Q1 = 1.44, 95% CI: 1.11, 1.88; P-trend 0.006) but no association for aggressive prostate cancer (OR for Q4 vs Q1 = 1.03, 95% CI: 0.73, 1.47; P-trend 0.89). Although not statistically significant, temporal analyses showed a stronger association between sarcosine and prostate cancer for serum collected closer to diagnosis, suggesting that sarcosine may be an early biomarker of disease. Interestingly, the association between sarcosine and prostate cancer risk was stronger among men with diabetes (OR= 2.66, 95% CI: 1.04, 6.84) compared to those without reported diabetes (OR=1.23, 95% CI: 0.95-1.59, p-interaction=0.01). This study found that elevated levels of serum sarcosine are associated with an increased prostate cancer risk and evidence to suggest that sarcosine may be an early biomarker for this disease.
Carcinogenesis , résumé, 2013