Sigmoidoscopy Screening: Understanding the Trade-off Between Detection of Advanced Neoplasia and Diagnostic Efficiency
A partir de données portant sur 5 059 participants à un essai randomisé comparant le test immunochimique et une coloscopie, cette étude compare, du point de vue du nombre de néoplasies proximales de stade avancé détectées, trois stratégies d'orientation vers une coloscopie après une sigmoïdoscopie
Sigmoidoscopy may reduce the incidence and mortality of colorectal cancer (CRC) in two ways. The first is by direct detection of distal (left-sided) early-stage CRC and removal of precancerous adenomatous polyps. The second takes advantage of the association between distal neoplastic findings and advanced neoplasia in the proximal colon. Several studies have shown a synchronous relationship between distal neoplastic findings and advanced proximal neoplasia (APN), in which the risk (or prevalence) of APN increases as the extent of distal neoplasia increases ...
Journal of the National Cancer Institute , commentaire, 2013