Public health implications from COGS and potential for risk stratification and screening
Cet article analyse, du point de vue de la santé publique et des stratégies de détection précoce, les implications des travaux du Consortium COGS ("Collaborative Oncological Gene-environment Study") sur l'identification de variants génétiques associés à un cancer du sein, de l'ovaire ou de la prostate
The PHG Foundation led a multidisciplinary program, which used results from COGS research identifying genetic variants associated with breast, ovarian and prostate cancers to model risk-stratified prevention for breast and prostate cancers. Implementing such strategies would require attention to the use and storage of genetic information, the development of risk assessment tools, new protocols for consent and programs of professional education and public engagement.
Nature Genetics , article en libre accès, 2012