Fruit and Vegetable Intake and Breast Cancer Risk: A Case for Subtype-Specific Risk?
A partir des données de 20 études de cohorte incluant 993 466 participantes (durée de suivi : entre 11 et 20 ans), cette étude évalue l'association entre la consommation de fruits et de légumes et le risque de cancer du sein en fonction du statut du récepteur hormonal (19 869 cas de cancer du sein ER+, 4 821 cas de cancer du sein ER-)
In this issue of the Journal, Jung et al. (1) report no overall effect of fruit and vegetable consumption on breast cancer risk among women in the large, long-term Pooling Project of Prospective Studies of Diet and Cancer (Pooling Project). When the authors considered hormone-responsive, estrogen receptor (ER)–positive patients separately from the nonhormonal, ER-negative patients under a hypothesis of separate etiology, a statistically significant protective effect of fruit and vegetable consumption was observed for risk of ER-negative, but not ER-positive breast cancer. Most striking, the authors provide evidence that the protective effect of fruit and vegetable consumption for ER-negative breast cancer, in terms of magnitude and direction, were largely consistent across the 20 pooled studies...
Journal of the National Cancer Institute , éditorial, 2013