Is the European Pediatric Medicine Regulation working for children and adolescents with cancer?
Cet article analyse les effets de la réglementation européenne relative aux médicaments pédiatriques, adoptée en 2007, sur les autorisations de mise sur le marché de traitements anticancéreux
The European Pediatric Medicine Regulation was launched in 2007 to provide better medicines for children. Five years later, the number of new anticancer drugs in early development in the pediatric population remains low and most children with cancer are still largely denied access to innovative drugs in Europe, as compared to the US. We analyzed individual PIP and waiver decisions for oncology drugs as well as all oncology drugs which have been approved for marketing authorization since 2007 in Europe. Among the 45 approved Pediatric Investigation Plans (PIPs), 33% concern leukemias and lymphomas, 29% solid tumors, 13% brain tumors and 20% a drug for supportive care. There is no specific PIP for life-threatening diseases such as high-risk neuroblastoma while there are several PIPs in extremely rare malignancies in children and adolescents such as GIST, melanoma, thyroid cancer and chronic myeloid leukemia. This paradoxical situation is due to approval of a PIP being driven by the adult indication. Twenty-six out of 28 authorized new oncology drugs have a potentially relevant mechanism of action for pediatric malignancies but 50% have been waived because the adult condition does not occur in children. The most striking example is crizotinib. The implementation of the pediatric regulation should no longer be driven by the adult indication, but should be guided by the biology of pediatric tumors and the mechanism of action of a drug. This will be achievable through voluntary PIPs submitted by Pharma or revocation of the oncology class waiver list.
Clinical Cancer Research , résumé, 2013