Current pre-clinical models for the advancement of translational bladder cancer research
Cet article passe en revue les travaux récents sur les modèles précliniques développés pour l'étude des cancers de la vessie
Bladder cancer is a common disease representing the 5th most diagnosed solid tumor in the United States. In spite of this, advances in our understanding of the molecular etiology and treatment of bladder cancer have been relatively lacking. This is especially apparent when recent advances in other cancers, such as breast and prostate, are taken into consideration. The field of bladder cancer research is ready and poised for a series of paradigm-shifting discoveries that will greatly impact the way this disease is clinically managed. Future pre-clinical discoveries with translational potential will require investigators to take full advantage of recent advances in molecular and animal modeling methodologies. We present an overview of current pre-clinical models and their potential roles in advancing our understanding of this deadly disease and for advancing care.
Molecular Cancer Therapeutics , résumé, 2012