Intensity of conditioning for allogeneic haemopoetic cell transplantation
Mené sur 195 patients atteints d'une leucémie myéloïde aiguë, cet essai randomisé de phase III évalue, du point de vue de l'incidence de la mortalité sans récidive, un protocole de conditionnement d'intensité réduite visant à minimiser les effets toxiques associés à une greffe allogénique de cellules hématopoïétiques
For many years, the toxic effects of allogeneic haemopoietic cell transplantation (HCT) restricted use to patients younger than 50 years without substantial comorbidities in addition to their underlying disease (frequently acute myeloid leukemia [AML] in first complete remission). The discovery1 of a substantial anti-AML effect mediated by the donor's lymphocytes (graft-versus-leukaemia effect) led to reductions in the intensity and thus the toxic effects of conditioning regimens, which were previously believed to be solely responsible for the anti-AML effect of HCT...
The Lancet Oncology , commentaire en libre accès, 2011