Control of Acute Myeloid Leukemia Relapse — Dance between KIRs and HLA
Mené sur 1 277 patients atteints d'une leucémie myéloïde aiguë ayant reçu une greffe allogénique de cellules souches hématopoïétiques, cet essai évalue l’association entre le statut du gène KIR2DS1 chez le donneur et le risque de récidive
The antileukemic effect of allogeneic hematopoietic stem-cell transplantation (HSCT) is provided by T cells and natural killer (NK) cells. Although T cells recognize malignant cells with tumor antigens presented by HLA molecules, NK cells recognize the “loss of self” HLA induced by transformation, stress, or infection.1 The net balance of inhibitory and activating signals determines the NK-specific target-cell response. The gene content of the killer-cell immunoglobulin-like receptor (KIR) family of inhibitory or activating NK-cell receptors can be used to define two KIR haplotypes.2 KIR A haplotypes include only one activating KIR gene, KIR2DS4; KIR B haplotypes include a variable . . .
New England Journal of Medicine , éditorial, 2011