Transrectal sonoelastography in the detection of prostate cancers: a meta-analysis
A partir d'une revue systématique de la littérature (6 études, 527 patients), cette méta-analyse évalue la sensibilité et la spécificité d'une élastographie ultrasonore transrectale pour détecter un cancer de la prostate
Study Type – Diagnostic (exploratory cohort)Level of Evidence 3aWhat's known on the subject? and What does the study add?The accuracy of transrectal sonoelastography (TRSE) in the detection of prostate cancer is variable, with a sensitivity ranging from 51.1 to 91.7% and specificity ranging from 62.2 to 86.8%.This is the first meta-analysis to assess the overall accuracy of TRSE in the detection of prostate cancer. OBJECTIVE * •To assess the overall accuracy of transrectal sonoelastography (TRSE) targeted biopsy in the diagnosis of patients suspected of having prostate cancer (PCa). METHODS * •A systematic search of electronic databases, including PubMed, Embase and The Cochrane Library, and manual bibliography searches were performed. * •All relevant studies assessing the diagnostic accuracy of TRSE in PCa detection were included in our meta-analysis. * •The data were pooled and sensitivity, specificity, area under the curve (AUC), positive likelihood ratio (LR) and negative LR were calculated. RESULTS * •Pooled patient data analysis: the pooled (95% confidential intervals [95% CI]) sensitivity of TRSE targeted biopsy in patients suspected of having PCa was 62 (55–68) %; specificity was 79% (74–84%); AUC was 0.7696; positive LR was 2.92 (2.28–3.74); and negative LR was 0.49 (0.41–0.59). * •Pooled core data analysis: pooled (95% CI) sensitivity, specificity, positive LR and negative LR were 34% (30–38%), 93% (91–95%), 5.07 (3.91–6.57) and 0.71 (0.66–0.75), respectively. CONCLUSION * •Transrectal sonoelastography is a promising technique in PCa detection and can be considered to be a valuable supplemental method to systemic biopsy.
BJU International , résumé, 2011