Advances in molecular imaging for breast cancer detection and characterization
Cet article passe en revue les travaux récents sur les diverses modalités d'imagerie moléculaire pour la détection et le diagnostic du cancer du sein
Advances in our ability to assay molecular processes, including gene expression, protein expression, and molecular and cellular biochemistry, have fueled advances in our understanding of breast cancer biology and have lead to identification of new treatments for breast cancer patients. The ability to measure biologic processes without perturbing them in vivo allows for the opportunity to better characterize tumor biology and to assess how biologic and cytotoxic therapies alter critical pathways of tumor response and resistance. By accurately characterizing tumor properties and biologic processes, molecular imaging plays an increasing role in breast cancer science, clinical care in diagnosis and staging, assessing therapeutic targets, and evaluating responses to therapies. This review describes the current role and potential of molecular imaging modalities for detection and characterization of breast cancer, focusing primarily on radionuclide-based methods.
Breast Cancer Research , article en libre accès, 2011