A paradigm shift in tumour response evaluation of targeted therapy: the assessment of novel drugs in exploratory clinical trials
Cet article passe en revue les diverses techniques permettant d'évaluer l'activité antitumorale d'un agent thérapeutique au cours d'un essai de phase II
Purpose of review: To describe the difficulty in assessing the biological activity of a novel agent in phase II trials. Recent findings: Two major fields of research provide interesting new potential endpoints: endpoints based on new imaging techniques (e.g. PET or spectral imaging that explore tumour metabolism, dynamic contrast enhanced (DCE) ultrasonography or DCE-MRI that explore tumour vascularization and tumour growth inhibition) and endpoints integrating assessment of tumour burden across time, such as the growth modulation index. Summary: Most of the recently described techniques appear attractive, but require formal validation. (C) 2012 Lippincott Williams & Wilkins, Inc.
Current Opinion in Oncology , résumé, 2011